Measurement results, cavas in Helsingin Sanomat rating
Biohit Oyj measured acetaldehyde concentration levels in the Spanish cavas involved in the Helsingin Sanomat rating (HS 24.4.2014). In 2009, the International Agency for Research on Cancer (IARC), which forms part of the World Health Organization, classified acetaldehyde included in and generated endogenously from alcoholic beverages as a Group I human carcinogen. Acetaldehyde belongs to the same risk class as, for example, asbestos and tobacco. One common principle applies to all Group I carcinogens: every available means should be used to avoid exposure to these substances.
Risk groups to alcohol-induced acetaldehyde are chronic PPI users as well as people suffering from gastric mucosal damage (atrophic gastritis) and dysfunction caused by acid-free stomach. Atrophic gastritis can be caused by Helicobacter pylori infection or by autoimmune disease. Atrophic gastritis as well as Helicobacter pylori are reliably found with the GastroPanel® test developed by Biohit.
Table 1. Free acetaldehyde concentrations in cavas analyzed by a gas chromatography.
|Rating||Product name||Acetaldehyde µM / l (mg/l)|
|3||Gramona Imperial Gran Reserva 2007||205 (9)|
|4||Pago de Tharsys Millésime Rosé Brut Reserva 2009||175 (7,7)|
|5||Freixenet Vintage Reserva 2011||83 (3,7)|
|6||Codorníu Selección Raventós Pinot Noir Brut||133 (5,9)|
|7||Castellblanc Rosado Cava Semi Seco||49 (2,2)|
|8||Cava Faustino Extra Seco||257 (11,3)|
|9||Cava Vallformosa Brut Vintage 2011||64 (2,8)|
|10||Freixenet Cordon Negro Brut||66 (2,9)|
Noteworthy in results is that every other cava the acetaldehyde concentration exceeds the cosmetic products special risk limit of 5 mg / l (SCCS 2012). For comparison purposes, a domestic sparkling wine Elysée was included, the acetaldehyde content of which is lowest in the range.
Alcohol researcher, Docent Peter Eriksson, University of Helsinki: “Acetaldehyde is a double-edged sword. In connection with drinking alcohol it will cause euphoric sensation, but also the unpleasant hangover symptoms can be partly attributed to it. It would be in many ways beneficial for health to find solutions in order to reduce acetaldehyde concentration. ”
CEO Semi Korpela, Biohit Oyj: ´Acetaldehyde effect is cumulative and the exposure is harmful to everyone. In particular at-risk groups should be able to make informed purchasing decisions and pay attention to the exposure to acetaldehyde. Acetaldehyde exposure can be tested at www.acetium.com. Recently, an Italian research group (Paiano et al. 2014) measured acetaldehyde in alcohol beverages. According to the study, results suggest that consumer guidance may be necessary.´
SCCS 2012: Scientific Committee on Consumer Safety – Opinion on Acetaldehyde (opens in a new window)
HS taste test April 25, 2014: www.hs.fi/ruoka/a1398227270363 (In Finnish, opens in a new window)
CEO Semi Korpela, Biohit Oyj
tel. +358 9 773 861
Methods and Equipment:Head-space gaschromatography adopted from Pikkarainen et al. (1979) and Jokelainen et al. (1994), as well as NIOSH ((National Institute of Occupational Health and Safety) (1994) methods.Clarus 500 Gaschromatoraph, BAC-2 capillary column, TurboMatrix HS-110 sampler (PerkinElmer Finland, Turku).
Calibrators and Controls:Acetaldehyde, CAS 75-07-0 (Supelco, Bellefonte, PA, USA, cat# 506788), purity 99,9%. The samples were prepared by weighing. Method Validation:According to Biohit’s quality system (ISO 9001:2008, ISO13485:2003).The validation was performed, when applicable, according to following standards and directives (the method is not accreditated):• Guidance for Industry. Q2B Validation of Analytical Procedures: Methodology. ICH November 1996.• 2002/657/EC Commission Decision of 12 August 2002, implementing Council Directive 96/23/EC concerning the performance of analytical methods and the interpretation of results (Text with EEA relevance).
Jokelainen K, Roine RP, Väänänen H, Färkkilä M, Salaspuro M. In vitro acetaldehyde formation by human colonic bacteria. Gut 1994; 35: 1271-4.NIOSH Manual of Analytical Methods (NMAM), Fourth Edition. ALDEHYDES, SCREENING: METHOD 2539, Issue 2, dated 15 August 1994 – 10 pages.Pikkarainen PH, Salaspuro MP, Lieber CS.A method for the determination of “free” acetaldehyde in plasma. Alcohol Clin Exp Res. 1979 Jul;3(3):259-61.
Read more: Specify the acetaldehyde concentrate in foodstuff with Biohit laboratory
Acetaldehyde Group I human carcinogen
In October 2009, the International Agency for Research on Cancer (IARC), which forms part of the World Health Organization, classified acetaldehyde included in and generated endogenously from alcoholic beverages as a Group I human carcinogen. Acetaldehyde belongs to the same risk class as, for example, asbestos and tobacco.Specific microbes (bacteria and yeasts) in the gastrointestinal tract are the most important source of acetaldehyde exposure to the human body. These microbes produce acetaldehyde from alcohol and, in certain circumstances, from sugar. Unlike the liver, the microbes and the intestinal mucosa cannot remove the acetaldehyde, and due to the effect of alcohol, an abundance of acetaldehyde accumulates in the saliva and elsewhere in the gastrointestinal tract. Acetaldehyde is a substance that accumulates in the body from several sources, continuous exposure to it thereby severely increasing the risk of cancer to various organs.
Source: IARC, Secretan et al (2009)
Read more: Research information on Acetium