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Peptest rapid test for reflux

Overview


PEPTEST is an innovative diagnostic test to help identify Reflux non-invasively. Peptest is based on quantitative lateral flow technology that detects the presence of pepsin in clinical samples from the upper digestive and respiratory tracts. 

Gastric juice, containing ingested foods, acid and pepsin, can reflux from the stomach into the oesophagus, larynx and primary airways. Pepsin, the enzyme responsible for the digestion of dietary proteins, is the leading aggressive agent responsible for damage to oesophageal and laryngeal tissue. In excess, gastric reflux can cause a wide range of conditions.

How does Peptest work?

Pepsin that reaches areas outside the stomach is a highly predictive marker of gastric reflux. Saliva and sputm samples can be tested for the presence of Pepsin quickly and non-invasively using Peptest and based on the concentrations found it is possible to determine the severity of reflux.

Peptest utilises a double monoclonal antibody capture technique incorporated into a lateral flow device. Thre results of the test are quantified using a small lateral-flow-reader that can be used in the lab, clinic or GP practice.

Peptest can be used to detect and measure Pepsin in a wide range of clinical samples including:

  • Saliva
  • Sputum
  • Tracheal aspirate
  • Oesophageal aspiration
  • Gastric juice
  • Exhaled air condensate
  • Bronchoalveolar fluid

Peptest can help in the following fields of medicine:

Gastroenterology - Peptest helps diagnose and direct treatment in patients suffering from GORD (gastroesophageal reflux disease).
Ear, Nose and Throat (ENT) - For patients suffering with sore throats, persistent coughs, a sensation of a lump in their throat or asthma, Peptest can help in the ENT specialist in their investigations of Laryngopharyngeal reflux (known as "Silent Reflux"). Peptest is a reliable method for diagnosing LPR.
Respiratory - Peptest can also be used for non-acid reflux studies on patients with respiratory conditions. Non-acid reflux is considered one of the commonest causes of chonic cough and is also indicated in voice disorders. In such patients Peptest delivers an objective and quantifiiable measure of pepsin to help identify the cause.

Use Peptest to detect the presence of pepsin and help diagnose a wide spectrum of pathological conditions:

  • GORD (gastroesophageal reflux)
  • LPR (Laryngopharyngeal Reflux)
  • Chronic cough
  • Cystic fibrosis
  • Post-lung transplant rejection
  • Asthma
  • Sinusitus

Ordering Information

Code Description
PEP50 Rapid quantitative immunological test for the detection of pepsin in saliva/sputum samples. 50 tests.
PEPCUBE Reader and data software for the quantitative analysis of Peptest.

Clinical background

Gastroesophageal reflux disease (GORD) has a high prevalence in the general population of Western countries and manifests as oesophageal and extra-oesophageal disorders. It is caused by reflux of gastric contents from the stomach into the oesophagus and respiratory tract causing extremely varied symptoms. Some people suffer occasionally whilst others suffer on an ongoing basis and based on symptoms alone it is dificult to make a specific diagnosis of the cause. The causes are many and include nutrition, lifestyle, stress, medication etc.
 
The most prevalent symptoms of gastroesophageal reflux disease (GORD) are heartburn and regurgitation, but when the reflux reaches the larynx and the airways the symptoms change distracting the individual from the source of the problem, for example in the case of Laryngopharyngeal Reflux (LPR) or Reflux of the airways. These cases may present as a sore throat, chronic cough, hoarseness, the feeling of having something lodged in the throat, dysphonia, difficulty in swallowing, asthma, otalgia, loss of tooth enamel, and COPD exacerbation (chronic obstructive pulmonary disease).
 
Left undiagnosed and untreated, reflux disease can damage the oesophagus (erosive oesophagitis) and the epithelium may progress to metaplasia called Barett's oesophagus. This condition is considered a facilitating factor in the development of oesophageal and laryngeal carcinoma.
 

Clinical applications

Ear, Nose and Throat (ENT)
Respiratory
Gastroenterology

Ordering


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