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Faecal Calprotectin ELISA

Overview

Marker of Bowel Inflammation

Calprotectin is a calcium binding protein and is the major protein of the neutrophil cytosol.  It is excreted in excess into the bowel lumen during the inflammatory process and is therefore an accurate surrogate marker for inflammatory and neoplastic gastrointestinal diseases.   Clinically it is of high value for reliably differentiating intestinal diseases.

It is often very difficult to distinguish between irritable bowel syndrome and chronic inflammatory bowel disease. This leads in many cases to extensive and unnecessary colonoscopies. The Faecal Calprotectin test allows clear differentiation between the two patient groups.

Applications

Diagnostic:  Differentiate IBS from IBD, reducing the numbers of unnecessary colonoscopies 

Prediction of IBD Relapse:  Allows targeted treatment to avert clinical relapse in IBD 

Chronic Disease Management:  Monitor the progress of known IBD patients in order to predict and treat flare-ups, and assess recovery 

Quick, convenient and reliable

  • 96 well Monoclonal Ab ELISA
  • Cut-off at 50μg/g to exclude inflammation
  • Incubation times: 30 + 30 + 10 mins 
  • 5 standards, 2 controls
  • Ready to use reagents
  • Room temperature incubations
  • Broad linear range - measures up to 2100μg/g 
  • Fewer false positives, fewer sample repeats
  • Easily automatable 
  • Rapid and user-friendly sample extraction tubes available 

Clinical background

Faecal calprotectin testing is recommended by NICE to help distinguish between inflammatory bowel diseases, (e.g. Crohn’s disease and ulcerative colitis), and non-inflammatory bowel diseases (e.g. IBS).

Three related pathways have been developed by NICE for the management of the following conditions:

  1. Crohn's disease
  2. IBS in adults
  3. Ulcerative colitis

Fewer referrals for Endoscopy through effective patient stratification

With a specificity that has shown to be considerably higher than other tests the Immundiagnostik ELISA results in the fewest number of false positive results and therefore the fewest unnecessary referrals.  This save costs, reduces risks and allows doctors to prioritise patients for referral with a higher likelihood of organic disease.  In addition, the high sensitivity means that very few patients are falsely ruled out as having IBS when combined with routine workup such as the Rome criteria.

Benefits

The diagnostic utility of Faecal Calprotectin brings measurable benefits to patients and Healthcare systems and provides an immediate cost saving.  A Faecal Calprotectin test costs considerably less than a colonoscopy/flexible sigmoidoscopy, and has also been shown to be more cost effective than traditional inflammatory marker tests (such as CRP).

  • Improve the positive predictive value of IBD consultations 
  • Rule out intestinal inflammation with high accuracy 
  • Paediatric and pregnant patient management made easy with this non-invasive test 
  • Adds value to CDAI assessments 
  • Helps Guide treatment changes and monitor response 
  • Direct further imaging investigations 

Ordering


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Cat. No. K6927

Faecal Calprotectin ELISA Kit 96 wells

Price £550.00 ex VAT

More info