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Human Neurotransmitter Substances

Yleistä

Neural and neuroendocrine cells are able to synthesize a variety of peptides as well as amino acids that can function either as inhibitory or stimulatory substances in neurotransmission. Such neurotransmitter substances are gammaamino butyric acid (GABA(12)) and calcitonin gene-related peptide (CGRP).

Ohjeet

Monoclonal antibody to GABA (GAMMA-AMINOBUTYRIC ACID) clone 5A9 (IgG1)

100 µg immunoglobulin in 1 ml PBS solution containing 1.0% (w/v) BSA and 0.1% (w/v) sodium azide.

The product is for research use only. The performance characteristics of this product have not been established. Use in human clinical diagnosis is the responsibility of the user. This product should be stored
at +2 … +8 °C.

Monoclonal antibody to GABA is derived from the hybridoma produced by fusion between myeloma cells and Balb/c spleen cells. GABA-coupled to BSA with glutaraldehyde was used as an immunogen.

Specificity
The antibody is highly specific to GABA and does not react with other amino acid-BSA conjugates with the exception of weak reaction against b-alanine BSA-conjugate at the highest concentrations used.

Applications
Fluorescence microscopy and other immunohistochemical methods, works also on frozen sections if perfusion fixed. Glutaraldehyde must be included in the fixative with paraffin sections.

References

  1. Jongen-Relo A. L. et al. (1999) J. Comp.Neurol. 408, 237-271.
  2. Miettinen M. et al. (1997) J. Comp. Neurol. 378, 363-378.
  3. Tuunanen J. et al. (1996) Eur. J. Neurosci. 8, 2711-2725.
  4. Pitkänen A. and Amaral D. (1994) J. Neurosci. 14, 2200.
  5. Erikson K. S. and Panula P. (1994) J. Comp. Neurol. 345, 526-536.
  6. Szabat E. et al. (1992) Neurosci. 47 , 409-420.
  7. Halasy K. et al. (1992) Eur. J. Neurosci. 4, 144.
  8. Airaksinen M. et al. (1992) J. Comp. Neurol. 323, 103.


Monoclonal antibody to CGRP ( CALCITONIN GENE RELATED PEPTIDE )clone CD8 (IgG1)

100 µg immunoglobulin in 1 ml PBS solution containing 1.0% (w/v) BSA and 0.1% (w/v) sodium azide.

The product is for research use only. The performance characteristics of this product have not been established. Use in human clinical diagnosis is the responsibility of the user. This product should be stored
at +2 …+8 °C.

Monoclonal antibody to CGRP is derived from the hybridoma produced by fusion between myeloma cells and Balb/c spleen cells. A terminal fragment of CGRP-coupled to BSA with glutaraldehyde was used as an immunogen.

Specificity
The antibody is highly specific to CGRP and does not react with other neuropeptides. The antibody works at least on human and guinea pig tissues, but does not work on rat tissues.

Applications
ELISA, fluorescence microscopy, and other immunohistochemical methods, works also on frozen sections if perfusion fixed. Paraformaldehyde must be included in the fixative with paraffin sections. Works also in western blotting with BSA-conjugated samples.

References

  1. Szabat E. et al. (1994) Histochem. J. 26, 317-326.

Tilaus

Tuote Spesifisyys Klooni Host Alaluokka Formaatti Määrä Sovellukset Parafiini Tilausnro Kysely
Human Neurotransmitter Substances GABA 5A9 mouse IgG1 purified 100 μg IHC, EIA yes 610025 Kysely
Human Neurotransmitter Substances GABA 5A9 mouse IgG1 purified 1mg IHC, EIA yes 610052 Kysely
Human Neurotransmitter Substances CGRP CD8 mouse IgG1 purified 100 μg IHC, WB, EIA yes 610026 Kysely
Human Neurotransmitter Substances CGRP CD8 mouse IgG1 purified 1mg IHC, WB, EIA yes 610053 Kysely

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