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Acetium

Overview

Nearly a hundred thousand Finns suffer from damage to and functional disorder of the gastric mucosa (atrophic gastritis) caused by a Helicobacter pylori infection or autoimmune disease, which among other things leads to an acid-free stomach. 

An acid-free stomach is the primary risk factor in gastric cancer. According to recent research, it is also a significant risk factor in oesophageal cancer.

Additionally, nearly half a million Finns use regular medications which reduce gastric acid secretion while also causing an acid-free stomach.

  • Matrix granules in a hard HPMC capsule
  • Active ingredient 100mg of plant-derived natural amino-acid L-cysteine made in Germany 
  • CE marked medical device
  • Does not contain animal-derived substances, lactose, gluteine, sugar or allergens
  • Package size 60 capsules
  • Dosage 1-2 capsules with meal

Acetium® is a CE marked product developed and patented by Biohit Oyj. It is intended for persons with a low-acid or anacidic stomach.

Acetium capsules include 100mg of natural amino acid as an active ingredient. L-cysteine reacts with acetaldehyde, forming harmless 2-methylthiazolidine-4-carboxylic acid (MTCA) and thus reducing the amount of acetaldehyde in the stomach.

Acetium capsules include matrix granules in which the L-cysteine is bound with a matrix former (Eudragit® RS) and  an inactive excipient. This causes L-cysteine to be released at a sustained rate and locally in the stomach - exactly where acetaldehyde is formed.

Acetium is currently available for sale in Finland, Germany and France. 

More information: www.acetium.com
 
 

Instructions

Acetium ® is a CE marked product developed and patented by Biohit Oyj. It is intended for persons with a low-acid or anacidic stomach.

Acetium capsules include 100mg of natural amino acid as an active ingredient. L-cysteine reacts with acetaldehyde, forming harmless 2-methylthiazolidine-4-carboxylic acid (MTCA) and thus reducing the amount of acetaldehyde in the stomach.

Acetium capsules include matrix granules in which the L-cysteine is bound with a matrix former (Eudragit® RS) and an inactive excipient. This causes L-cysteine to be released at a sustained rate and locally in the stomach - exactly where acetaldehyde is formed.

The effective operation of cysteine

After its release from the granules, L-cysteine dissolves quickly in the stomach and reacts with acetaldehyde. Based on permeability studies on the Caco-2 cell line, it has been proven that L-cysteine does not absorb in the stomach to any significant extent, since the stomach mucosa does not include the LAT2 amino acid transporter responsible for the absorption of cysteine in the small intestine. Thus, L-cysteine released from the Acetium capsules exits the stomach only by binding with acetaldehyde or advancing to the small intestine along with food.

Clinical studies have proven that when administered on an empty stomach with ethanol solution, Acetium capsules containing 200mg of L-cysteine can bind acetaldehyde for at least 45 minutes.
At the end of the test, all test persons still had measurable concentrations of L-cysteine in the stomach. In actual usage, food in the stomach slows down L-cysteine's transfer to the small intestine. Therefore Acetium capsules are effective for even longer.

The MTCA formed from acetaldehyde and L-cysteine is excreted in the urine and feces.
Cysteine is a natural amino acid L-cysteine is a natural amino acid, 1-2g of which is digested daily along with proteins in regular food.

Furthermore, it is a generally used food additive (E920) and has been approved by the European Food Safety Authority (EFSA) as a food additive suitable for both adults and children.

Additionally, the US Food and Drug Administration (FDA) has certified L-cysteine as safe and granted it a GRAS classification (Generally Regarded as Safe).
 
 

Clinical background


  • Alongside asbestos and tobacco, acetaldehyde is a Group I human carcinogen.
  • Exposure to acetaldehyde occurs on a much larger scale than exposure to asbestos and smoking.
  • On a global scale, exposure to acetaldehyde is linked to approximately 4 million new cancer cases annually, or nearly 40 per cent of all cancers
  • Awareness of the dangers posed by acetaldehyde should have a major global effect on the food industry and people's behaviour. By influencing both of these, exposure to acetaldehyde can be notably decreased.

In October 2009, the International Agency for Research on Cancer (IARC), the international cancer research unit which forms part of the World Health Organization, classified acetaldehyde included in and generated endogenously from alcoholic beverages as a Group I human carcinogen.
Acetaldehyde belongs to the same risk class as, for example, asbestos and tobacco.

Specific microbes (bacteria and yeasts) in the gastrointestinal tract are the most important source of acetaldehyde exposure to the human body. These microbes produce acetaldehyde from alcohol and, in certain circumstances, from sugar. Unlike the liver, the microbes and the intestinal mucosa cannot remove the acetaldehyde, and due to the effect of alcohol, an abundance of acetaldehyde accumulates in the saliva and elsewhere in the gastrointestinal tract.

Acetaldehyde is a substance that accumulates in the body from several sources, continuous exposure to it thereby severely increasing the risk of cancer to various organs. Risks posed by acetaldehyde can be compared with those posed by cholesterol

In the light of scientific evidence, health risks related to acetaldehyde correspond to those related to cholesterol but, compared to cholesterol, awareness of acetaldehyde is non-existent.
Therefore, health education related to acetaldehyde should be increased dramatically.
Abstention from smoking, moderate use of alcohol, excellent oral hygiene and avoidance of foods and alcoholic beverages containing acetaldehyde are key factors in reducing the cancer risk caused by acetaldehyde.

In particular, health education should be aimed at known risk groups, or at carriers of the gene mutation increasing acetaldehyde exposure and people suffering from an acid-free stomach. 

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